Candida and Alzheimer’s?

This post will likely be startling and even a bit frightening, but every bit of it is still true. Here’s the startling and frightening part: the fungus Candida and the dreadful Alzheimer’s disease have a common denominator – a certain kind of plaque known as Alzheimers’s plaque! There’s lots of current research trying to understand why and how the brain makes this plaque. And while they are searching for answers, other researchers have now discovered that Candida makes it all the time! Actually, Candida is quite good at making the Alzheimer’s variety of plaque. This is a quick read, and will give you something to think about – while you can still do that.

Pathology is the science that studies the cause and effect of disease. It would be helpful if you put on your pathologist’s hat as you read this blog. And if such a hat doesn’t exist, just make believe you’re wearing one. There’s also a bit of investigating work to be done, so keep your investigator hat ready.

So now that you are wearing your hat, you are ready for work, and this is what we are looking for: a killer that has already attacked millions. The killer has a name: Alzheimer’s disease (“AD” for short). One of the first victims to be studied was in the early 1900’s by German psychiatrist Alois Alzheimer. Think of Alois as the first  member of a Crime Scene Investigation team to arrive at the crime scene. He did much of the groundwork studies upon which other researchers built our current understanding of this disease.

NIH Aging Brain healthy, Severe ADIn a little more than a century after Alois’s work, the disease has spread so widely that the Obama Administration in May of 2012, announced a coordinated Government effort which will probably involve thousands of medical researchers to find ways to at least slow down it’s deadly pace, if not treat and cure it. The White House also set a target date of year 2025 to accomplish that goal. By then it is anticipated that 16 million Americans will have the disease, up from 5 million today. Real numbers, real people, real tragedies! And the killer is still on the loose!

So far the actual cause of AD is unknown. Thus it’s not surprising that there is no known cure for this dreadful way for ending life. It may be slow but it’s relentless; it eventually destroys the human brain and central nervous system.

Here is something that researchers have discovered: One of the main characteristics of AD is the presence of a sticky plaque found in the brains of deceased AD patients. But it’s not just any type of plaque, nor a variety of several types of plaque, amyloid-plaques-credit slideshare.netthere’s just one type of plaque associated with AD. The plaque which has been found is a particular protein-like kind of plaque known as amyloid beta plaque. The dominate theory among current medical researchers is that this plaque is the fundamental cause of the disease. However at present time, no specific theory has explained nor demonstrated why the plaque is the cause of AD symptoms. But apparently this sticky amyloid beta plaque is always found in the brains of AD patients.

From Wikipedia: Alzheimer’s Disease (obviously not a medical journal, but something you can easily check out for yourself):

“In 1991, the amyloid hypothesis postulated that amyloid beta (Aβ) deposits are the fundamental cause of the (Alzheimer’s) disease.Support for this postulate comes from the location of the gene for the amyloid beta precursor protein (APP) on chromosome 21, together with the fact that people with trisomy 21 (Down Syndrome) who have an extra gene copy almost universally exhibit AD by 40 years of age. Also APOE4, the major genetic risk factor for AD, leads to excess amyloid buildup in the brain. Further evidence comes from the finding that transgenic mice that express a mutant form of the human APP gene develop fibrillar amyloid plaques and Alzheimer’s-like brain pathology with spatial learning deficits…”

OK, that was Wikipedia bringing you up to date with some of the basic thinking on Alzheimer’s and what causes it. So just in case you didn’t understand every word, here is the currently accepted thinking: Amyloid plaque deposits found in AD patients’ brains are most likely what caused their disease, and eventual deaths. And as current thinking goes, AD has to do with human genetics: goof-ups in our chromosomes etc.  In other words, the human body for unknown reasons goes haywire and brings AD on itself! The body starts depositing these sticky and bad amyloid (beta) plaques throughout the brain. They may accumulate slowly, but they are still deadly.

Remember, there are 2 big unknowns about AD: 1st, – what causes the disease? and 2nd – how to cure it or at least treat it?  Here’s two more closely related questions if we assume that the sticky amyloid plaque is the cause of AD: Questions such as how does the plaque get inside the brain? And if the body is making this plaque, then how does it make it, and WHY? Great questions!

The same amyloid (beta) plaque?

As a reader of theCandidaZone.com, there are a few items about the fungus Candida  that you might find quite interesting with the subject of Alzheimer’s . Recently, there has been lots of research about Candida which has discovered that the fungus produces amyloid plaque of the exact same variety found in the brains of deceased persons who had Alzheimer’s! The exact same stuff!!  See for yourself! You can listen to a report by a medical research team on iTunes (download iTunes for free here) and catch the details. It’s easy & free, here’s how: After downloading, open iTunes and click the iTunesU buttoneffort iTunesU and Med Grand Rounds
which is the button on the top right side of the iTunes player, as in the photo above. From the drop down menu select Health & Medicine, then look for “Medicine Grand Rounds.”  Or just do a search in the iTunes search box (top-right corner of the iTunes player). Search either  for “Medicine Grand Rounds” or “University of Arizona.” Then scroll down the hundreds of topics until you find the episode titled: “Candidiasis, Important Clinical and Basic Science Perspectives.”

Most of this report is pretty deep stuff and might not make sense to a non-medical science type person. So if that describes you, be patient as you listen to words you might of never heard before.  But if you dont want to wait, you can fast-forward the video!! So fast forward to 7:20 minutes and listen to the presentation (the entire video is only 47 minutes long – it’s worth the time). So whether you fast forward or not, watch closely for this title: “Adhesin of Candida albicans” as below: Medicine Gr Rds 2

 

Now listen closely as Dr. Klotz explains the functions of this adhesin structure on the surface of Candida. At 7 minutes, 27 seconds into the video, he mentions an area on the Candida adhesin that, “ . . . amazingly enough, a small segment here, that forms amyloids, just like Alzheimer’s disease . . . “  Did you hear that? If not, go back and listen again.

And it’s not just one solitary, isolated and unique adhesin which makes these amyloids!  As the next speaker, Dr. Lipke mentions (at several times from 20 thru 24 minutes): “Candida albicans . . . we now know from work in a lot of labs, doesn’t have an adhesin, it has dozens of adhesins. It wants to stick to anything it can stick to.” Dr. Lipke also makes the point that among the many things these adhesins do is: they make amyloids, the same kind as found in Alzheimer’s! In this same video, at 27 minutes, watch for this screen shot title: Then, Als T regions form amyloids (yes, like those in Alzheimer’s plaques) Medicine Gr Rds 3

Listen carefully as Dr. Lipke explains how and where the Candida fungus makes this amyloid plaque.

So, to answer the question, “Does Candida make the same kind of plaque as Alzheimer’s plaque?”  The answer is clearly written in the 2nd line of the title of the screen shot (you must be at least 27minutes and 20 seconds into this video to see the correct screen shot):

“(yes, like those in Alzheimer’s plaques)

 Now before we go any further, please understand that Drs. Klotz and Lipke did not say that Candida causes Alzheimer’s! They did explain that Candida makes the same amyloid (beta) plaque as found in brains of deceased AD patients. But that doesn’t mean Candida is the cause. Two different thoughts.

Smoking guns . . . and matching bullets??!!

So back to the Alzheimer’s crime scene. That’s where we find all of this bad amyloid beta plaque deposited inside the brains of Alzheimer’s victims. According to current expert opinion, the plaque is the main reason the human body shows the symptoms of the disease known as Alzheimer’s. Typically over time, these amyloid plaque deposits slowly but surely destroy the brains’ ability to function and eventually the person dies from it.

As we find out more about AD victims, we find lots of amyloid deposits in their brains. Since these deposits are believed to be the cause of the disease, (and eventually the cause of death), let’s call these amyloid deposits “bullets.” Just like real metal bullets, the amyloid kind are also deadly.

Speaking of bullets, if you have watched enough TV or videos of a crime scene investigation you know how the investigators can often match a fired bullet to the gun it was fired from by microscopic examination of the bullet. Here’s how: when they suspect matching bulletsa certain gun they have taken possession of for evidence, they fire the same type of bullets thru the gun into a special test chamber, then retrieve these test bullets to see if the barrel marks on the side of these bullets match the marks of the crime scene bullets. And if they match? They have good reason to believe the gun is the same one used at the crime. Of course they examine the gun itself for fingerprints to see who last used it. You already know that whoever owns the fingerprint will be a “person of interest” the detectives and investigator people will want to interrogate. This is nothing new to you – you’ve already seen it in the movies.

Many researchers including Drs. Klotz and Lipke, have shown that the Candida fungus makes the same type of amyloid plaque (“bullets”)! Candida is very good at making alzheimer’s plaque.

Now a few questions.  But first, let’s make sure that we are on the same page. Let’s review what is theory, and what isn’t. It will be quite helpful to understand the difference.

1st: “Alzheimer’s is caused by the amyloid plaque deposits found in the brain.” This is theory. There is a lot of research and homework leading to this conclusion, but remember it’s still just theory.

2nd: “These amyloid plaque deposits are somehow made when the chromosomes and other genetic stuff of the person start to malfunction.”  This is also theory. Again, there’s lots of research pointing to this conclusion, but it’s still just theory.

3rd: “The fungus Candida makes the exact same type of amyloid plaque that has been found in the brains of Alzheimer’ victims.” THIS IS NOT THEORY! This is what research labs have discovered as they study Candida. They can put Candida in the laboratory, give it food, the right temperature, etc., and it will grow. And as it grows, it makes amyloid (beta) plaque. The plain and simple truth is that Candida makes the exact same type of amyloid plaque also known as alzheimer’s plaque. THIS IS NOT THEORY!

So now the questions: Did these amyloid (beta) plaque deposits (let’s call them ‘bullets’) come from the human chromosomes somehow going haywire which caused the body to shoot itself? . . .  or from Candida?

What if both the body and Candida are found to have shot these plaque “bullets?” Then who fired the first shots? What if the body was already weakened and vulnerable from it’s own chromosomes – gone – crazy shooting spree, then along came Candida and pounced because the body’s defense had started breaking down thus making it an easy ‘hit’?  Lot’s of other questions, but this will at least get us to start thinking.

At the start of this post, we wanted to explain what the fungus has in common with the disease.  Heres the common denominator: a certain type of plaque, amyloid (beta) plaque, also known as Alzheimer’s plaque. The fungus is good at making the plaque, and the identical type of plaque is found in the brains of  people who have died from Alzheimer’s.

Starting to get suspicious about Candida? You’re not the only one.

 

 

 

 

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